ndothelial Expression of Bone Morphogenetic rotein Receptor Type 1a is Required for trioventricular Valve Formation

نویسندگان

  • Patricia A. Thistlethwaite
  • Kan Kaneko
  • Xiaodong Li
  • Xiaoxue Zhang
  • John J. Lamberti
  • Stuart W. Jamieson
چکیده

2008;85:2090-2098 Ann Thorac Surg Patricia A. Thistlethwaite Kan Kaneko, Xiaodong Li, Xiaoxue Zhang, John J. Lamberti, Stuart W. Jamieson and Required for Atrioventricular Valve Formation Endothelial Expression of Bone Morphogenetic Protein Receptor Type 1a is http://ats.ctsnetjournals.org/cgi/content/full/85/6/2090 located on the World Wide Web at: The online version of this article, along with updated information and services, is

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bone morphogenic protein receptor type 1a (BMPR1A) and Caveolin-1 associated with trastuzumab resistance of breast cancer cells

Trastuzumab is a specific monoclonal antibody used for therapeutic of the human epidermal growth factor receptor 2 (HER-2) -positive metastatic breast cancer. But, resistance to trastuzumab is a major obstacle in clinical efficiency.  During the past years, several studies have been done to find the mechanisms contributing to trastuzumab resistance. Previous studies have highlighted that bone m...

متن کامل

Single Nucleotide Polymorphism Analysis of the Bone Morphogenetic Protein Receptor IB and Growth and Differentiation Factor 9 Genes in Rayini Goats (Capra hircus)

The FecB, a mutation in the bone morphogenetic protein receptor IB (BMPR-IB) gene, which increases the fecundity of Booroola Merino sheep, and FecGH, a mutation in the Growth and Differentiation Factor 9 (GDF9), which affects the fecundity of Cambridge and Belclare sheep in a dose sensitive manner, were analyzed as candidate genes associated with the prolificacy in Rayini goats. These polymorph...

متن کامل

Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification.

OBJECTIVE Calcific aortic valve disease (CAVD) is the most prevalent type of heart valve disease, affecting ≈2% of the US population. CAVD is characterized by the presence of calcific nodules, resulting in aortic valve (AoV) stenosis; however, the underlying mechanisms driving disease remain unknown. Studies of human diseased AoV provide initial evidence that bone morphogenetic protein (BMP) si...

متن کامل

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation.

Lymphatic vessels are critical for the maintenance of tissue fluid homeostasis and their dysfunction contributes to several human diseases. The activin receptor-like kinase 1 (ALK1) is a transforming growth factor-β family type 1 receptor that is expressed on both blood and lymphatic endothelial cells (LECs). Its high-affinity ligand, bone morphogenetic protein 9 (BMP9), has been shown to be cr...

متن کامل

Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice.

We describe the effects of the overexpression of noggin, a bone morphogenetic protein (BMP) inhibitor, on osteoblast differentiation and bone formation. Cells of the osteoblast and chondrocyte lineages, as well as bone marrow macrophages, showed intense beta-gal histo- or cytostaining in adult noggin+/- mice that had a LacZ transgene inserted at the site of noggin deletion. Despite identical BM...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008